Cowingene Monkeypox Virus Typing Detection Kit (NATBox)

The Cowingene Monkeypox Virus Typing Detection Kit (MPXV Typing Detection Kit) is intended for in vitro qualitative detection of Monkeypox Clade I, Monkeypox Clade II and other Orthopoxvirus in Lesion material (swabs of surface or exudate, or crusts), Anorectal swab, Oropharyngeal swab. It can differentiate between Monkeypox Clade I, Monkeypox Clade II and other Orthopoxvirus. The function of the assay is for the aid for diagnosis of suspected Monkeypox or other Orthopoxvirus infection.
Orthopoxviruses (OPXV) are very large (200 nm like small bacteria), brick-shaped ds DNA viruses with a genome of ~ 200 kb. They cause febrile illnesses with prominent vesicular rash. Orthopoxviruses that are known to cause disease in humans include smallpox, vaccinia virus, cowpox , and monkeypox.
Monkeypox virus (MPXV) is a zoonotic virus in the family Poxviridae, genus Orthopoxvirus. The virus causes a disease in humans that is similar to smallpox, but results in a lower case-fatality rate. With the eradication of smallpox and widespread discontinuation of smallpox vaccination, human monkeypox has re-emerged as a human health threat with major outbreaks occurring in 1996–1997 and 2022. More recently, MPXV was found to be the cause of a cluster of cases of disease in many countries. There are two known clades of MPXV: clade I, previously known as the Congo Basin clade; and clade II, previously called the West African clade.

The Mpox Typing Detection Kit is performed on the NATBox System. It is an automated in vitro diagnostic test system.
The NATBox Systems automate and integrate sample preparation, nucleic acid extraction and amplification, and detection of the target sequences in samples. The systems require the use of single-use cartridges that hold the PCR reagents and host the PCR process. Because the cartridges are self-contained, cross-contamination between samples is minimized. For a full description of the system, please see the product manual of NATBox System.

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Specification

Recommended Supporting  Reagents